Pulmonary Rehabilitation in Advanced Lung Cancer Survivors

Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmonary rehabilitation is a type of supportive treatment that may improve these symptoms. This study has two parts. The first part is a randomized trial where half of the participants receive eight weeks of pulmonary rehabilitation. The other half of participants do not do pulmonary rehabilitation and instead receive the treatment that their doctors would normally recommend. The purpose of this part of the research study is to understand if pulmonary rehabilitation can help people with advanced stage NSCLC have better functioning and less shortness of breath. The other part of the research study is an interview study. The purpose of doing interviews is to understand any challenges or obstacles that people with advanced stage NSCLC may have regarding pulmonary rehabilitation, as well as oncology care providers have with their participants going to pulmonary rehabilitation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Participants must have histologically confirmed NSCLC, Stages III or IV treated with palliative intent

• Adults ≥ 18 years of age

• ECOG performance status ≤ 3

• Clinical stability: defined as no clinical/radiographic progression within the last three months

• Self-reported dyspnea, defined as score ≥ 2 on the modified Medical Research Council (mMRC) Dyspnea Scale

• Participants must be fluent in written and spoken English

Locations
United States
Ohio
University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
RECRUITING
Cleveland
Contact Information
Primary
Melinda Hsu, MD, MS
Melinda.hsu@uhhospitals.org
216-286-6505
Backup
Peronne Joseph
Peronne.Joseph@uhhospitals.org
216-844-8573
Time Frame
Start Date: 2025-10
Estimated Completion Date: 2028-12
Participants
Target number of participants: 85
Treatments
Experimental: Pulmonary Rehabilitation (PR)
Active_comparator: Usual care
No_intervention: Qualitative interviews
A subset of PR participants, a subset of participants who decline the randomized portion of the study, and a subset of medical care providers will participate in qualitative interviews to assess attitudes and barriers to PR.
Sponsors
Collaborators: United States Department of Defense
Leads: Case Comprehensive Cancer Center

This content was sourced from clinicaltrials.gov

Similar Clinical Trials